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Optical excitation of organic semiconductors as a highly selective strategy to induce vascular regeneration and tissue repair
We describe how photoexcitation of the conducting polymer poly(3-hexylthiophene-2,5-diyl), also known as P3HT, stimulates extracellular Ca2+ entry through Transient Receptor Potential Vanilloid 1 (TRPV1) channels upon the production of hydrogen peroxide (H2O2) in the cleft between the nanomaterial and the cell membrane. H2O2-induced TRPV1-dependent Ca2+ entry stimulates ECFC proliferation and tube formation, thereby providing the proof-of-concept that photoexcitation of organic semiconductors may offer a reliable strategy to stimulate ECFCs-dependent neovascularization in CVDs.PMID:35589009 | DOI:10.1016/j.vph.2022.106998
Source: Vascular Pharmacology - May 19, 2022 Category: Drugs & Pharmacology Authors: Francesco Moccia Sharon Negri Pawan Faris Carlotta Ronchi Francesco Lodola Source Type: research
Epistatic Interaction Between 5-HT1A and Vascular Endothelial Growth Factor Gene Polymorphisms in the Northern Chinese Han Population With Major Depressive Disorder
Conclusions: The interactions between 5-HT1A and VEGF gene polymorphisms may play a key role in the development of MDD in the Northern Chinese Han population.IntroductionMajor depressive disorder (MDD) is one of the most common complex mental disorders, with symptoms that include loss of interest, periodic depression, and thoughts of suicide. Epidemiologic studies have shown that MDD afflicted an estimated 7%–11% of the general population (1, 2); yet, the underlying mechanism of MDD remains unclear. Genetic factors are likely to play a critical role in its etiology with the total contribution of heritability estimat...
Source: Frontiers in Psychiatry - April 15, 2019 Category: Psychiatry Source Type: research
Regulator of Angiogenesis and Vascular Function: A 2019 Update of the Vasoinhibin Nomenclature
Jakob Triebel1*, Juan Pablo Robles2, Magdalena Zamora2, Gonzalo Martínez de la Escalera2, Thomas Bertsch1 and Carmen Clapp2
1Institute for Clinical Chemistry, Laboratory Medicine and Transfusion Medicine, General Hospital Nuremberg and Paracelsus Medical University Nuremberg, Nuremberg, Germany
2Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro, Mexico
Proteolytic cleavage of prolactin (PRL), the human anterior pituitary hormone fundamental for lactation can generate vasoinhibin, a peptide-hormone with endocrine, paracrine, and autocrine ef...
Source: Frontiers in Endocrinology - April 9, 2019 Category: Endocrinology Source Type: research
< em > Sb < /em > -Phenyl- < em > N < /em > -methyl-5,6,7,12-tetrahydrodibenz < em > c,f < /em > 1,5azastibocine Induces Perlecan Core Protein Synthesis in Cultured Vascular Endothelial Cells
Int J Mol Sci. 2023 Feb 11;24(4):3656. doi: 10.3390/ijms24043656.ABSTRACTVascular endothelial cells synthesize and secrete perlecan, a large heparan sulfate proteoglycan that increases the anticoagulant activity of vascular endothelium by inducing antithrombin III and intensifying fibroblast growth factor (FGF)-2 activity to promote migration and proliferation in the repair process of damaged endothelium during the progression of atherosclerosis. However, the exact regulatory mechanisms of endothelial perlecan expression remain unclear. Since organic-inorganic hybrid molecules are being developed rapidly as tools to analyz...
Source: Atherosclerosis - February 25, 2023 Category: Cardiology Authors: Takato Hara Tomoko Konishi Shuji Yasuike Yasuyuki Fujiwara Chika Yamamoto Toshiyuki Kaji Source Type: research
Dr. Epstein, Political Bias, & Google Search Results
I’m a little confused by claims made by Dr. Robert Epstein and his assertion, based upon a single study of 95 participants, that Google somehow intentionally biased the results shown before the 2016 U.S. presidential election. And therefore, likely impacted the election results itself.
That’s a huge assertion to make. One would hope that an esteemed researcher such as Dr. Epstein would have the scientific data to back it up. Unfortunately, I don’t see it.
Science is only objective up until the point where a scientist acknowledges and accounts for her or his own biases. Science is not based on a preset ag...
Source: World of Psychology - August 22, 2019 Category: Psychiatry & Psychology Authors: John M. Grohol, Psy.D. Tags: General Policy and Advocacy Psychology Technology google bias Robert Epstein Source Type: blogs
Novel Coconut Vinegar Attenuates Hepatic and Vascular Oxidative Stress in Rats Fed a High-Cholesterol Diet
CONCLUSION: Novel coconut vinegar is the source of antioxidants, and daily supplementation of coconut vinegar was found to attenuate dyslipidemia-induced hepatic and vascular oxidative stress by protective against cellular lipid peroxidation.PMID:35356733 | PMC:PMC8959456 | DOI:10.3389/fnut.2022.835278
Source: Atherosclerosis - March 31, 2022 Category: Cardiology Authors: Wachirawadee Malakul Porrnthanate Seenak Noppadon Jumroon Siwaret Arikit Sarawut Kumphune Nitirut Nernpermpisooth Source Type: research
The SMILES Substructure Search Fallacy
ConclusionText matching on SMILES strings seems like a natural, simple solution to the substructure search problem. But this is a mirage. The futility of this approach may only become apparent after weeks or even months of effort. Regardless of the specific implementation, any robust solution must compare molecules as graphs.
Source: Depth-First - April 13, 2019 Category: Chemistry Authors: Richard L. Apodaca Source Type: blogs
Vascular endothelium as a target for perfluroalkyl substances (PFAs)
CONCLUSIONS: Serum concentration of PFHpA, a new, short-chain PFA, was associated with impaired vascular function among outpatients without CVD. Our findings support a potential adverse cardiovascular effect of newer, short-chain PFAs.PMID:35447152 | DOI:10.1016/j.envres.2022.113339
Source: Environmental Research - April 21, 2022 Category: Environmental Health Authors: Sharine Wittkopp Fen Wu Joseph Windheim Morgan Robinson Kurunthachalam Kannan Stuart D Katz Yu Chen Jonathan D Newman Source Type: research
Advances in the study of the vascular protective effects and molecular mechanisms of hawthorn ( < em > Crataegus anamesa < /em > Sarg.) extracts in cardiovascular diseases
This study aimed to review the vascular protective effects and molecular mechanisms of hawthorn and its extracts on cardiovascular diseases (CVDs). Hawthorn has a wide range of biological functions. Evidence suggests that the active components of HE reduce oxidative stress and inflammation, regulate lipid levels to prevent lipid accumulation, and inhibit free cholesterol accumulation in macrophages and foam cell formation. Additionally, hawthorn extract (HE) can protect vascular endothelial function, regulate endothelial dysfunction, and promote vascular endothelial relaxation. It has also been reported that the effective ...
Source: Atherosclerosis - June 20, 2023 Category: Cardiology Authors: Mengkai Lu Lei Zhang Jinyuan Pan Huishan Shi Muxin Zhang Chao Li Source Type: research
Environmental dose of 16 priority-controlled PAHs mixture induce damages of vascular endothelial cells involved in oxidative stress and inflammation
Toxicol In Vitro. 2021 Dec 9:105296. doi: 10.1016/j.tiv.2021.105296. Online ahead of print.ABSTRACTEpidemiological studies have shown that cardiovascular diseases caused by PM2.5 pollution account for the second death rate in China. Polycyclic aromatic hydrocarbons (PAHs) are one important group of persistent organic pollutants absorbed on PM2.5. Though individual PAH is related to vascular disease, the relationship between environmental PAHs exposure and vascular damages is still unclear. To explore the effect of PAHs on blood vessel, human umbilical vein endothelial cells (HUVECs) are treated with 16 priority-controlled ...
Source: Toxicology in Vitro - December 13, 2021 Category: Toxicology Authors: Jiaying He Qihua Pang Chengmeng Huang Jiaqi Xie Jindian Hu Lei Wang Congcong Wang Lingxue Meng Ruifang Fan Source Type: research
